I posted the study I was apart of back in March 2020 as an exposed Healthcare worker.
It was part of the University of Minnesota
Posted from last time. Please post your cited rebuttal.
This is the trial that was published in the Summer.
From the Minnesota Dr who headed the Trial.
- This isn't treatment, it's prophylaxis, which is part of the reason we used 5 days (no need to prophylax for the entire incubation period from time of exposure.
- We used a loading dose on day 1, so we actually get to our target concentration very quickly.
- Our dosing regimen was based on PK modeling, which our pharmacy colleagues performed, targeting a quick and sustained concentration modeled after the 2005 Vincent and Yao in vitro papers on SARS-CoV-1 inhibition with hydroxychloroquine.
- Gautret's results are hard to interpret for any meaningfulness. They excluded those with negative results, altered treatments mid-study, did not describe how and where portions of their population were tested (some had reported Ct values, some did not), and seems to have chosen his regimen without much consideration of the prior literature.
This is the conclusion of the prophylaxis study, and not the other one.
This randomized trial did not demonstrate a significant benefit of hydroxychloroquine as postexposure prophylaxis for Covid-19. Whether preexposure prophylaxis would be effective in high-risk populations is a separate question, with trials ongoing. In order to end the pandemic, a reduction in community transmission is needed.
You can go to the same medical site and find the results that were just finalized for treatment in hospitals.
Hydroxychloroquine can cause retinopathy
Early symptoms include floaters, blurriness, dark areas of vision, and difficulty perceiving colors. Blindness can occur. Mild cases may be treated with careful diabetes management. Advanced cases may require laser treatment or surgery.
Hydroxychloroquine contraindications:
- low blood sugar
- G6PD deficiency
- low amount of magnesium in the blood
- low amount of potassium in the blood
- porphyria
- anemia
- low levels of a type of white blood cell called neutrophils
- alcoholism
- myasthenia gravis
- a skeletal muscle disorder
- maculopathy
- changes in the visual field
- prolonged QT interval on EKG
- chronic heart failure
- abnormal EKG with QT changes from birth
- liver problems
- decreased kidney function
- psoriasis
- seizures
- anemia from pyruvate kinase and G6PD deficiencies
- chronic kidney disease stage 5 (failure)
Ivermectin if not measured in the appropriate doses, or managed incorrectly can lead to liver, and renal failure.
Ivermectin Contraindications:
- asthma
- hepatic disease
- HIV
- Immunosuppressed patients
- pregnancy
- breastfeeding
- neonates, infants, children
- loa loa coinfection
- onchodermatitis
Now can this be a decent approach to helping people maybe, but these are not cure all wonder drugs.
HCQ, Azithromycin, and zinc did better at my hospital than anything with Ivermectin
But statistically they did not have that much if any significant effect, and we sent most of the research to the University of Minnesota.
Remdesivir was not that great either in fact it was the worst out of all listed so far.
The one thing that seemed to have the biggest effect was donated plasma from recovered SARS-CoV2 patients.
You are wanting to give Ivermectin to Covid patients, but many of them that end up in a stepdown, or ICU level treatment floors are already battling organ failure especially liver, and renal failure.
This is coming from the hospital that was the first in the world to put a SARS-CoV2 patient on ECMO.